Effect of catalpol on senile plaques and spatial learning and memory ability in amyloid-β protein precursor/presenilin 1 double transgenic mice
10.3760/cma.j.issn.1006-7876.2013.04.012
- VernacularTitle:梓醇对淀粉样蛋白前体/早老素1双转基因小鼠老年斑和学习记忆的影响
- Author:
Chong SONG
;
Yanan CHU
;
Guiqiong HE
;
Gang LIU
;
Lingxi WANG
;
Zefen ZHOU
;
Qiuhui YAO
- Publication Type:Journal Article
- Keywords:
Catalpol;
Amyloid beta-protein precursor;
Presenilin-1;
Mice,transgenic;
Senile plaques;
Learning;
Memory
- From:
Chinese Journal of Neurology
2013;(4):265-268
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether catalpol affects senile plaque formation and spatial learning and memory ability in the amyloid-β protein precursor/presenilin 1 (APP/PSI) double transgenic mice.Methods Three month-old APP/PS1 double transgenic mice were randomly divided into catalpoltreated and saline-treated groups (n =10),with C57 mice of the same age and genetic background as normal control group (n =10).The catalpol (in a dose of 5 mg · kg-1 · d-1) and the same amount of saline were peritoneally injected into Alzheimer' s disease (AD) model mice for 3 weeks.Immunohistochemical staining was performed to examine senile plaques in the brain of AD model mice,and Morris water maze was used to assess the spatial learning and memory abilities of the mice.Results Compared with the saline-treated AD model mice (6.0 ±0.6),the number of senile plaques of catalpol treated AD mice significantly decreased (2.3± 0.7; t =3.500,P =0.025); Mice in each groups had similar latency and path length to reach platform in visible platform test; In hidden platform test,catalpol-treated mice had a significant lesser latency and path length compared with saline-treated mice,furthermore,catalpol-treated mice had much more platform-crossing times (6.4 ± 0.8) than saline-treated mice (2.9 ± 0.4 ; t =5.592,P =0.001).Conclusion Catalpol can significantly decrease the senile plaque formation and improve the spatial learning and memory abilities of APP/PS1 double transgenic mice.
