Hypergammaglobulinemia: a sentinel detecting autoimmune pancreatitis
10.3760/cma.j.issn.1007-631X.2013.01.007
- VernacularTitle:识别自身免疫性胰腺炎的哨兵指标——高γ球蛋白血症
- Author:
Wenchuan WU
;
Xiuzhong YAO
;
Dayong JIN
;
Dansong WANG
;
Wenhui LOU
;
Xinyu QIN
- Publication Type:Journal Article
- Keywords:
Pancreatitis;
Autoimmune diseases;
Hypergammaglobulinemia;
Diagnosis
- From:
Chinese Journal of General Surgery
2013;(1):20-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the clinical value of hypergammaglobulinemia as a sentinel for autoimmune pancreatitis and avoid unnecessary pancreas resection.Methods All 14 patients with autoimmune pancreatitis or related pancreatic diseases underwent routine examinations,including liver function,CA199 and imaging.Measurement of serum IgG or IgG4 was performed for patients with clinically suspected or pathologically proved autoimmune pancreatitis.Clinical features were retrospectively compared between the AIP and non-AIP patients using x2 statistics with Yates correction or Fisher exact test.Results Ten cases were finally confirmed as autoimmune pancreatitis.All patients with autoimmune pancreatitis had elevated levels of serum γ-globulins,while only one case without autoimmune pancreatitis had elevated levels of serum γ-globulins.It was proved by subsequent antibody tests that serum IgG/IgG4 and γ-globulins were simultaneously increased.Conclusions Hypergammaglobulinemia can be used as a preoperative sentinel indicator for differentiating autoimmune pancreatitis from pancreatic malignancies and avoiding unnecessary pancreas operation.
