Association study of the genetic polymorphism of D2S1338 and D19S433 loci and the initiative-aggressive behavior in male population

VernacularTitle:男性主动攻击行为与D2S1338、D19S433基因座的关联研究
Author: Chun YANG ; Huajie BA ; Haiying YU ; Zhiqin GAO ; Hanqing ZHAO ; Wei GUO
Publication Type:Journal Article
Keywords: Initiative-aggressive behavior; Chromosomes,human; Microsatellites repeats; Polymorphism,genetic; Case-control studies
From: Chinese Journal of Behavioral Medicine and Brain Science 2013;(2):127-130
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship of the initiative-aggressive behavior and D2S1338,D19S433 loci.Methods PCR and electrophoresis method were used to conduct genotype analysis on D2S1338 and D19S433 in the peripheral blood of 187 male initiative-aggressive violent offenders and 459 healthy men living in Jiangsu area.Results D2S1338 and D19S433 loci in initiative-aggressive behavior group and healthy group were found to coincide with Hardy-Weinberg equilibrium (P ＞ 0.05).There were significant difference in locus D19S433 (P ＜ 0.05)between initiative-aggressive behavior group and healthy group,but not on locus D2S1338 (P＞0.05).Univariate analysis showed significant differences at allele 14.2 and genotype 14-14 on locus D19S433 between the two groups (P =0.0011,P =0.0008) with the OR values being 0.50 (95 ％ CI:0.33-0.76) and 3.49(95％ CI:1.62-7.52),respectively.Conclusion Locus D19S433 may be related to with initiative-aggressive behavior with allele 14.2 being the resistant factor and genotype 14-14 being the susceptible factor.