The influence of 3 ％ hypertonic saline and 20 ％ mannitol on cerebral oxygen metabolism in patients undergoing neurosurgery for supratentorial glioma

VernacularTitle:静脉输注高渗氯化钠注射液与甘露醇对颅脑手术患者脑氧代谢的影响
Author: Can LI ; Rong ZHENG
Publication Type:Journal Article
Keywords: Hypertonic saline; Mannitol; Intracranial pressure; Cerebral oxygen metabolism
From: Chinese Journal of Primary Medicine and Pharmacy 2013;20(2):240-241
CountryChina
Language:Chinese
Abstract: Objective To study the effect of 3％ hypertonic saline(HS) and 20％ mannitol on cerebral oxygen metabolism in patients undergoing neurosurgery for supratentorial glioma.Methods 56 patients undergoing neurosurgery for supratentorial glioma were evenly divided into two groups.Group A(n =28) was treated by 3％ hypertonic saline(5.35ml/kg).Group B (n =28) was treated by 20％ mannitol(1 g/kg).CSFP was tested before hypertonic saline or mannitol infusion (T0),immediately (T1),15,30,60,120min after infusion (T2 ～5).Various blood-gas indexes were observed at To,T3 ～5.CaO2,CjvO2,Da-jvO2 and CERO2 were calculated.Results CSFP significantly dropped from T2 to T5 in both groups (P ＜ 0.05).Da-jvO2 and CERO2 were significantly reduced at T4～5 in both groups (P ＜ 0.05).There was no significant difference between the two groups.Conclusion 3 ％ HS is as efficient as 20％ mannitol in reducing intracranial pressure and improving cerebral oxygen metabolism in patients undergoing neurosurgery for supratentorial glioma.