Application of decitabine in the treatment of hematological malignancies
10.3760/cma.j.issn.1006-9801.2013.02.023
- VernacularTitle:地西他滨在恶性血液肿瘤治疗中的应用
- Author:
Bing ZHOU
- Publication Type:Journal Article
- Keywords:
Hematologic neoplasms;
Decitabine;
Methylation
- From:
Cancer Research and Clinic
2013;(2):136-138
- CountryChina
- Language:Chinese
-
Abstract:
Decitabine is a methylation inhibitor,which is different from traditional chemotherapy drugs,with new and unique mechanism of action,and represent a new therapeutic concept.Methylation present in almost all cells,by inhibiting DNA methyltransferase,causing hypomethylation of DNA and cell differentiation or apoptosis to anti-tumor effect.In this paper,methylation inhibitor decitabine treatment of hematological malignancies in the application are reviewed.
