DNA methylation in pancreatic carcinogenesis
10.3760/cma.j.issn.1006-9801.2013.02.022
- VernacularTitle:DNA甲基化与胰腺癌发病的关系
- Author:
Xia CHEN
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
DNA methylation
- From:
Cancer Research and Clinic
2013;(2):133-135
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic cancer is one of the most malignant gastrointestinal tumors,characterized by a poor prognosis,absence of specific clinical symptoms and signs,prone to metastases and lack of response to conventional therapy.1 year survival rate of this disease increased to about 20 ％ by gemcitabine,but the morbidity and mortality rates are still higher and higher in the whole worldwide.DNA methylation is one of the mechanisms of epigenetics which is the study of heritable changes in gene expression that are not coded in the DNA sequence itself.It seems that DNA methylation indeed plays an important role in the development and progression of pancreatic cancer.
