Typing of amyloidosis in renal biopsies of 205 cases

VernacularTitle:205例肾脏淀粉样变性病患者的分型诊断研究
Author: Ying YAO ; Suxia WANG ; Youkang ZHANG ; Zhen QU ; Gang LIU ; Wanzhong ZOU
Publication Type:Journal Article
Keywords: Amyloidosis; Biopsy; Immunohistochemistry; Mutation
From: Chinese Journal of Nephrology 2013;(2):88-92
CountryChina
Language:Chinese
Abstract: Objective To identify the prevalence of different amyloid types in renal biopsies.Methods The renal biopsies of 205 patients diagnosed as renal amyloidosis from January 1990 to December 2011 were reassessed.Immunohistochemistry was performed with a penal of antibodies directed against λ-light chain,κ-light chain,amyloid A,fibrinogen,transthyretin,apolipoprotein A1,and lysozyme.Immune electron microscopy and gene analysis were performed when the results of immunohistochemistry were indeterminate.Results Among 205 patients,190 cases (92.7％) were classified as immunoglobulin light chain amyloidosis (AL),1 (0.5％) case as amyloid A amyloidosis and 1 (0.5％) case as fibrinogen A α-chain amyloidosis.The amyloid types of remaining 13 (6.3％) cases were undetermined.In the AL patients,the distribution of λ and κ was 6.6∶1.Conclusion AL is the most common form of renal amyloidosis in China,with a predominant light chain type of λ.