Uses of half-dose gonadotropin-releasing hormone agonist with different treatment cycles after conservative laparoscopic surgery in the treatment of endometriosis

VernacularTitle:子宫内膜异位症术后应用不同治疗周期半剂量促性腺激素释放激素激动剂的疗效观察
Author: Qin ZHU ; Hongxia ZHANG ; Xia LIU ; Liping WANG
Publication Type:Journal Article
Keywords: Endometriosis; Gonadotropin-releasing hormone
From: Chinese Journal of General Practitioners 2013;(2):140-142
CountryChina
Language:Chinese
Abstract: To explore the efficacy of using gonadotropin-releasing hormone agonist (GnRH-a) with different cycles after conservative laparoscopic surgery in the treatment of endometriosis.Research was conducted on 108 patients with endometriosis Ⅲ or Ⅳ diagnosed by conservative laparoscopy from January 2010 to June 2011.Among them,57 patients (group A) were managed with GnRH-a postoperatively for 3 months and the others (group B) 6 months.Clinical efficacy,relapse rate and pregnancy rate after withdrawal were compared between two groups.The clinical efficacy rate of groups A and B were 73.7％ and 90.2％ respectively.And there were significant statistical differences between them.However,the relapse rate of groups A and B were 14.0％ and 5.9％ and the pregnancy rate of two groups 45.0％ and 4/12 respectively.And there were no statistical differences.A 6-month regimen of GnRH-a can reduce and delay the recurrence of endometriosis and improve the clinical efficacy.A short-term dosing of GnRH-a is indicated for those patients with fertility requirements.