Serum level changes of leptin and 5-hydroxytrytamine in patients with premature ejaculation before and after hydrochloride sertraline treatment
10.3760/cma.j.issn.1671-7368.2013.02.020
- VernacularTitle:盐酸舍曲林治疗前后早泄患者血浆瘦素及5-羟色胺水平的变化
- Author:
Yong ZHOU
;
Kunlong TANG
;
Baolong WANG
;
Lin YANG
;
Liming LI
;
Changhai YANG
- Publication Type:Journal Article
- Keywords:
Premature ejaculation;
Intravaginal ejaculation latency time;
Leptin;
5-hydroxy trytamine
- From:
Chinese Journal of General Practitioners
2013;(2):130-131
- CountryChina
- Language:Chinese
-
Abstract:
A total of 71 patients with premature ejaculation (PE) received hydrochloride sertraline treatment for 8 weeks and their serum levels of leptin and 5-hydroxytrytamine (5-HT) were determined.Their ejaculation functions were assessed with intravaginal ejaculation latency time (IELT) and Chinese index of premature ejaculation (CIPE-5) value.The study was compared with 64 normal males as control.The baseline level of leptin in the trial group was obviously higher than the controls (P ＜ 0.05) while the level of 5-HT in the trial group far lower than the controls (P ＜ 0.05).At 8 weeks,the level of leptin dropped while the level of 5-HT rose in the trial group after treatment.Therefore a high serum level of leptin and a low serum level of 5-HT may become biological indicators for PE.
