Correlation of blood lipids and insulin resistance in patients with impaired glucose tolerance
10.3760/cma.j.issn.1671-7368.2013.01.027
- VernacularTitle:糖耐量减低患者胰岛素抵抗与血脂的相关性研究
- Author:
Chunyan SHAN
;
Baocheng CHANG
;
Miaoyan ZHENG
;
Ying WANG
;
Juhong YANG
;
Huizhu REN
;
Liming CHEN
- Publication Type:Journal Article
- Keywords:
Glucose intolerance;
Insulin resistance;
Dyslipidemias
- From:
Chinese Journal of General Practitioners
2013;(1):63-65
- CountryChina
- Language:Chinese
-
Abstract:
Blood lipid level and its associations with insulin resistance were studied in patients with impaired glucose tolerance (IGT).Two hundred and twenty first degree relatives of type 2 diabetes mellitus were grouped into normal glucose tolerance (NGT) and IGT groups according to results of oral glucose tolerance test.Compared with the NGT group,the IGT patients had higher serum levels of total triglyceride (TG),total cholesterol (TC),low density lipoprotein-C (LDL-C) but a lower serum level of high density lipoprotein-C (HDL-C).Homeostasis model of assessment for insulin resistance index (HOMA-IR) and area under curve of insulin (AUCI) also increased.A positive relationship was found between TG and HOMA-IR (or AUCI),but a negative relationship existed between HDL-C and HOMA-IR.In conclusion,abnormal blood lipid metabolism is present in IGT patients and it has a close correlation with insulin resistance.
