Correlation of depression and cognitive function in patients with chronic obstructive pulmonary disease

VernacularTitle:慢性阻塞性肺疾病患者抑郁和认知功能损害研究
Author: Chuanqin XU ; Yuanqiang HE ; Yulong ZHENG ; Liyang ZHOU ; Shu LIU ; Yufeng WAN
Publication Type:Journal Article
Keywords: Pulmonary disease,chronic obstructive; Depression
From: Chinese Journal of General Practitioners 2013;(1):59-61
CountryChina
Language:Chinese
Abstract: Based upon the measure of depression as defined by Hamilton depression scale (HAMD)scores ＞ 17,120 patients with chronic obstructive pulmonary disease (COPD) were classified into 2 groups:COPD patients with or without depression.According to the mini-mental state examination (MMSE),the cognitive functions of all patients were evaluated.Meanwhile,oxygen saturation and pulmonary function were measured by blood gas analyzer and spirometer respectively.Fifty-four COPD patients were complicated with depression.HAMD scores were significantly negatively correlated with oxygen saturation and pulmonary function (P ＜0.05).Multiple regression analysis revealed that gender,oxygen saturation and MMSE scores were risk factors of depression (P ＜ 0.05).MMSE scores decreased more obviously in the COPD patients with depression and were positively correlated with oxygen saturation (P ＜ 0.01).A negative correlation existed between MMSE scores and HAMD scores (r =-0.549,P ＜ 0.05).