SCGB3A2: A validated susceptibility gene to Graves' disease in different ethnic populations
10.3760/cma.j.issn.1000-6699.2013.02.001
- VernacularTitle:SCGB3A2——一个与多人群、不同种族的Graves病发生密切相关的基因
- Author:
Shuangxia ZHAO
;
Huaidong SONG
- Publication Type:Journal Article
- Keywords:
Graves' disease;
Susceptibility gene;
Polymorphism,single nucleotide
- From:
Chinese Journal of Endocrinology and Metabolism
2013;(2):93-96
- CountryChina
- Language:Chinese
-
Abstract:
Graves' disease is a common autoimmune disease triggered by the susceptibility genes and environmental factors.Among the 9 risk genes related to Graves' disease,SCGB3A2 is the first Graves' disease-predisposing gene identified by our group using tagSNPs,strategy of candidate genes,and positional clones.The association between SCGB3A2 and Graves' disease has been confirmed by two independent cohorts from UK and Russia.So far,the geneticists on Graves' disease regard SCGB3A2 as a validated susceptibility gene of that disease.
