Association of serum apolipoprotein A5 with leptin and insulin in obese children

VernacularTitle:肥胖儿童血清载脂蛋白A5水平与瘦素和空腹胰岛素的相关性研究
Author: Jun ZHANG ; Guanghua LUO ; Lili PAN ; Jiang WEI ; Yuanping SHI ; Lu ZHENG
Publication Type:Journal Article
Keywords: Obesity; Apolipoprotein A5; Leptin; Fasting insulin
From: Chinese Journal of Endocrinology and Metabolism 2013;(1):62-63
CountryChina
Language:Chinese
Abstract: Totally 79 obese children and 64 children with normal body weight were included in the present study.Serum apolipoprotein A5 (ApoA5) and leptin levels were determined by ELISA and fasting insulin by RIA.The clinical data including height,body weight,waist circumference,blood pressure,blood lipid,blood glucose,etc,were collected.Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated.The results showed that compared with normal weight children,both serum leptin and insulin levels were significantly raised in obese children [19.15 (13.01 ～ 25.08) ng/ml vs 3.29 (1.45 ～ 6.02) ng/ml and 15.44 (12.05 ～ 20.26) μg/L vs 10.12 (8.60 ～ 12.60) μg/L,both P＜0.01],while ApoA5 level was significantly lowered [134.5 (105.9 ～ 172.7) ng/ml vs 2005.9(164.3 ～ 265.3) ng/ml,P＜0.01].Serum ApoA5 was negatively correlated with serum leptin and insulin (both P＜0.01).