Difference in proprotein convertase subtilisin/kexin type 9 levels between premenopausal and postmenopausal women

VernacularTitle:前蛋白转化酶枯草溶菌素9在绝经前后女性中的差异
Author: Wen GUO ; Zhenzhen FU ; Qin CUI ; Kunlin WANG ; Yan SUN ; Yina CHANG ; Hongwen ZHOU
Publication Type:Journal Article
Keywords: Proprotein convertase subtilisin/kexin type 9; Low density lipoprotein-cholesterol; Menopausal
From: Chinese Journal of Endocrinology and Metabolism 2013;(1):46-49
CountryChina
Language:Chinese
Abstract: Objective To compare proprotein convertase subtilisin/kexin type 9 (PCSK9) levels between premenopausal and postmenopausal women,and to investigate the relationship between serum PCSK9 and metabolic factors.Methods Totally 515 women were enrolled from the study on diabetes of prediction,prevention,and intervention in Nanjing in 2009.Survey,physical examinations,and determination of related metabolic indexes were performed.Serum PCSK9 level was measured by sandwich ELISA.Results Serum PCSK9 level was positively correlated with low density lipoprotein-cholesterol (LDL-C),total cholesterol (TC),triglyceride,fasting plasma glucose,body mass index,waist-hip ratio,and age in women (all P＜0.01).PCSK9 level was significantly lower in premenopausal women than that in postmenopausal women [(58.18 ± 25.44 vs 80.91 ± 33.74) ng/ml,P ＜0.01].Conclusion Higher level of PCSK9 exists in postmenopausal women compared with premenopausal women.The level of PCSK9 is closely correlated with age,TC,and LDL-C.