Median effective target effect-site concentration of sufentanil when intraoperative wake-up test was successful in patients undergoing scoliosis surgery
10.3760/cma.j.issn.0254-1416.2013.01.011
- VernacularTitle:脊柱侧弯矫形术患者术中唤醒试验成功时舒芬太尼的半数有效效应室靶浓度
- Author:
Weiqing MA
;
Chenghua ZHANG
;
Yunli YANG
;
Xi XI
;
Jie LIU
- Publication Type:Journal Article
- Keywords:
Sufentanil;
Drug delivery systems;
Dose-response relationship,drug
- From:
Chinese Journal of Anesthesiology
2013;(1):46-48
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the median effective target effect-site concentration (EC50) of sufentanil when intraoperative wake-up test was successful in patients undergoing scoliosis surgery.Methods Ninety ASA Ⅰ or Ⅱ patients,aged 18-64 yr,with body mass index ＜ 30 kg/m2,scheduled for scoliosis surgery under sevoflurane and sufentanil anesthesia,were randomly divided into Ⅰ-Ⅵ groups (n =15 each).Anesthesia was induced with sufentanil,etomidate and cisatracurium,and maintained with sevoflurane,sufentanil and cisatracurium.The patients were tracheal intubated and mechanically ventilated.Before the wake-up test,infusion of cisatracurium was stopped and the end-tidal concentration of sevoflurane was adjusted to 0.The EC50 was determined by the K(a)rber method.The target effect-site concentration of sufentanil was set at 0.19 ng/ml in group Ⅰ,0.18 ng/ml in group Ⅱ and gradually decreased in decrements of 0.01 ng/ml.The wake-up test was performed 5 min later.The EC50 and 95 ％ confidence interval of sufentanil were calculated by the K(a)rber method.Results EC50 of sufentanil obtained was 0.164 ng/ml and 95％ confidence interval of sufentanil obtained was 0.157-0.172 ng/ml when the wake-up test was successful.Conclusion The EC50 of sufentanil is 0.164 ng/ml when the intraoperative wake-up test is successful in the patients undergoing scoliosis surgery.
