Neurokinin B and its receptor in idiopathic hypogonadotropic hypogonadism
10.3760/cma.j.issn.1000-6699.2013.01.025
- VernacularTitle:神经激肽B及其受体与特发性低促性腺激素性性腺功能减退症
- Author:
Yihong JIANG
;
Shouyue SUN
;
Weiqing WANG
- Publication Type:Journal Article
- Keywords:
Idiopathic hypogonadotropic hypogonadism;
TAC3/TACR3 gene mutation;
Neurokinin B;
Pulsatile GnRH secretion
- From:
Chinese Journal of Endocrinology and Metabolism
2013;(1):88-90
- CountryChina
- Language:Chinese
-
Abstract:
Idiopathic hypogonadotropic hypogonadism (IHH) is characterized by delayed or absent puberty and lowered sexual function as a result of impaired pulsatile gonadotropin-realeasing hormone (GnRH) secretion.Identification of TAC3/TACR3 mutations as the culprits of IHH revealed that neurokinin B (NKB) signaling pathway was involved in the regulation of pulsatile GnRH secretion.This review focuses on the involvement of NKB signaling in pulsatile GnRH release,the discovery of TAC3/TACR3 mutations and the phenotypes,and treatment of patients who carry TAC3 or/and TACR3 mutations.
