Effects of flurbiprofen axetil preemptive analgesia on T cell immune functions in postoperative patients with upper abdominal
10.3760/cma.j.issn.1673-4904.2013.03.007
- VernacularTitle:氟比洛芬酯超前镇痛对上腹部术后患者T细胞免疫功能的影响
- Author:
Yuquan YANG
;
Jun ZHONG
;
Zaiwen ZHOU
- Publication Type:Journal Article
- Keywords:
Flurbiprofen;
Analgesia;
Immunity,cellular
- From:
Chinese Journal of Postgraduates of Medicine
2013;(3):19-21
- CountryChina
- Language:Chinese
-
Abstract:
ObJective To study the effects of flurbiprofen axetil preemptive analgesia on T cell immune functions in postoperative patients with upper abdominal.Methods Seventy-six patients with upper abdominal operation were divided into observation group (40 cases) and control group (36 cases) by random digits table,observation group and control group were given intravenous injection of 100 mg flurbiprofen axetil or 10 ml 0.9％ sodium chloride 10 min before skin incision respectively.Peripheral venous blood samples were collected for the determination of CD4+,CD8+,natural killer cell (NK cell) and CD4+/CD8+ by flow cytometry 1 day preoperative,2 and 48 h postoperative.Results In two groups,the CD8+ and NK cell of 2 h postoperative were lower significantly than those of preoperative (observation group:0.1850 ±0.0550 vs.0.2430 ±0.0856,0.1197 ±0.0673 vs.0.1598 ±0.0775；control group:0.1219 ±0.0571 vs.0.2385 ±0.0847,0.0778 ± 0.0311 vs.0.1621 ± 0.0806,P ＜ 0.05),however,the observation group was significantly higher than the control group (P ＜ 0.05).There was no significant difference in CD4+,CD8+ and NK cell of 48 h postoperative between two groups.Conclusion There are disorders on the T cell immune functions in postoperative patients with upper abdominal,but flurbiprofen axetil preemptive analgesia can improve the T cell immune function.
