Appling cell-free fetal DNA and RNA of maternal plasma in non-invasive prenatal diagnosis
10.3760/cma.j.issn.1009-9158.2013.01.004
- VernacularTitle:母血中胎儿游离DNA及RNA在无创性产前诊断中的应用
- Author:
Zhan ZHANG
;
Linlin ZHANG
- Publication Type:Journal Article
- Keywords:
Prenatal diagnosis;
Fetus;
DNA;
RNA
- From:
Chinese Journal of Laboratory Medicine
2013;(1):14-17
- CountryChina
- Language:Chinese
-
Abstract:
Genetic factors are the important reasons for birth defects.Among genetic factors,chromosome abnormality is the most common.Prenatal diagnosis can effectively avoid fetus of abnormal chromosome being born.Noninvasive prenatal diagnosis has more advantage than invasive prenatal diagnosis,such as non-invasive,painless and safe.It is bound to become the main method of prenatal diagnosis.However,non-invasive prenatal diagnosis is still in its infancy stage and the accuracy and sensitivity of detection are pending and need further clinical validation.This article will present a variety of non-invasive prenatal diagnostic methods using cell-free fetal DNA (RNA) and their advantages and disadvantages will be discussed.
