Initial clinic verification of internal target volume generated with four-dimensional CT and deformable registration
10.3760/cma.j.issn.1004-4221.2013.02.024
- VernacularTitle:自研发变形配准软件在四维CT图像上确定靶体积的初步临床验证
- Author:
Jun YANG
;
Xingwang GAO
;
Xiaowu DENG
;
Ming CHEN
;
Fugen ZHOU
- Publication Type:Journal Article
- Keywords:
Tomography,X-ray computed,four-dimensional;
Clinical target volume;
Internal target volume;
Deformable registration software
- From:
Chinese Journal of Radiation Oncology
2013;(1):80-83
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study preliminary the accuracy of clinical target volume (CTV) and internal target volume (ITV) automatically generated by an in-house deformable registration software on fourdimensional CT (4DCT),and evaluate its feasibility of clinical application.Methods Clinic treated one lung cancer patient and one liver cancer patient were selected for the study.CTV was delineated by radiation oncologist according to a single respiratory phase image of 4DCT scanning,and then deformed to the other phases and generated the CTVdefm on each phase image.Differences between the CTVdefm and CTVmanu were then compared.A composite ITVcopm was created by overlapping all the CTVdefm of 10 phases and compared with the ITVMIP which was contoured on the maximum intensity projection (MIP) CT images,including the shape,volume and geometric center position of the ITV contour.Results For the tested lung case,average volume difference between the CTVdefm and CTV was (-2.59 ± 5.02)％ for the all 10 phases,and the vector departure of the two ITV centers was (1.04 ± 0.89) mm.The ITVcomp almost completely matched the ITVMIP on the tested liver case with a volume difference smaller the 1％ and only 1.4 mm vector departure between their geometric centers.Conclusion The validity of the CTVdefm and ITVcomp gained from automatic deformation of manual delineation reference based on 4DCT images were preliminary evaluated and proved to be good enough for clinic planning.
