Serum levels of CXC chemokine ligand 10 and chemokine receptors in patients with type 1 diabetes mellitus

VernacularTitle:CXC趋化因子配体10及其受体在1型糖尿病患者血中水平的变化
Author: Fengyan ZENG ; Wenhui SONG ; Xiaojuan CHEN ; Mei FENG ; Bingmei YAN ; Caiyun LIU ; Aimin HAN
Publication Type:Journal Article
Keywords: CXC chemokine ligand 10; CXC chemokine receptor 3; Diabetes mellitus,type 1
From: Chinese Journal of Endocrinology and Metabolism 2013;(1):35-36
CountryChina
Language:Chinese
Abstract: Serum levels of CXC chemokine ligand 10 (CXCL10) and chemokine receptor 3 (CXCR3) were determined in 50 patients with type 1 diabetes mellitus (T1 DM) and 30 normal control subjects by ELISA method.The results showed that serum levels of CXCL10 and CXCR3 in T1DM patients were significantly higher than those in normal subjects [(258.17 ± 39.12 vs 96.47 ± 26.91) ng/L,(851.87 ± 70.04 vs 441.82 ± 72.24) pg/ml,both P＜0.05].Serum level of CXCL10 in patients dropped sequentially with durations of diabetes ＜6 weeks,≥6 weeks or ＜3 years,and ≥ 3 years,being statistically significant between groups (P＜0.05).These results suggest that serum levels of CXC10 and CXCR3 may reflect the immune activity in T1DM.