Relationship between FGF-21 and type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease

VernacularTitle:成纤维细胞生长因子21与2型糖尿病合并非酒精性脂肪肝关系的研究
Author: Hailin PAN ; Xiaocui LIU ; Hongye SU ; Yingrong LI ; Hongming DENG
Publication Type:Journal Article
Keywords: Fibroblast growth factor-21; Diabetes mellitus,type 2; Nonalcoholic fatty liver disease
From: Chinese Journal of Endocrinology and Metabolism 2013;(1):32-34
CountryChina
Language:Chinese
Abstract: The level of serum fibroblast growth factor-21 (FGF-21) in patients with type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease (NAFLD) was determined by ELISA.The results showed that serum FGF-21 level in these patients was higher than that in type 2 diabetic patients [(266.55 ± 21.24 vs 220.32 ± 22.68) ng/L,P＜ 0.01].Serum FGF-21 levels in both groups were significantly higher than that in normal control group [(173.52 ± 16.18) ng/L,P＜0.01].Serum FGF-21 level was positively correlated with waist circumference,blood glucose,and triglyceride.FGF-21 may contribute to the development of NAFLD in the patients with type 2 diabetes mellitus.