Drug resistance and carbapenemases genotypes of carbapenem-resistant Acinetobacter baumannii
10.3760/cma.j.issn.1674-2397.2013.02.012
- VernacularTitle:碳青霉烯类耐药鲍曼不动杆菌的耐药性及碳青霉烯酶基因型研究
- Author:
Sufei YU
;
Shixiao LI
;
Linyao HUANG
;
Minfei PENG
;
Chunyan XU
;
Xiaoli ZHU
- Publication Type:Journal Article
- Keywords:
Acinetobacter baumannii;
Drug resistance;
Carbapenems;
Genotype
- From:
Chinese Journal of Clinical Infectious Diseases
2013;(2):108-110
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate drug resistance and carbapenemase genotypes of carbapenemresistant Acinetobacter baumannii.Methods A total of 75 clinical isolated strains of carbapenem-resistant Acinetobacter baumannii were collected from Taizhou Hospital in Zhejiang province during January 2011 and June 2012.Vitek 2 Compact microbial identification system was used for bacterial identification and drug susceptibility test,and modified Hodge test was used to screen strains producing carbapenemases.Genotypes of carbapenamases were determined by polymerase chain reaction.Results All 75 carbapenem-resistant Acinetobacter baumannii strains were resistant to most antibacterial agents except amikacin.The resistant rate to amikacin was 13.3％ (10/75).OXA-23 gene was positive in 69 strains (92.0％),and OXA-51 gene was positive in 67 strains (89.3％).No IMP,VIM and SIM gene was observed.Conclusion OXA enzyme is the main cause of drug resistance in this group of carbapenem-resistant Acinetobacter baumannii,and OXA-23 and OXA-51 genes are the most popular carbapenemnases coding genes.
