Effects of edaravone postconditioning and remote ischemic postconditioning on myocardial ischemia/reperfusion injury in rats
10.3760/cma.j.issn.0254-1416.2013.01.027
- VernacularTitle:依达拉奉后处理联合远隔缺血后处理对大鼠心肌缺血再灌注损伤的影响
- Author:
Hengchang LI
;
Lixin XU
;
Zhiping LI
;
Shu ZHANG
;
Kun SUO
;
Shouzhang SHE
;
Xiaodong FU
- Publication Type:Journal Article
- Keywords:
Free radical scavengers;
Myocardial reperfusion injury;
Ischemic postconditioning
- From:
Chinese Journal of Anesthesiology
2013;(1):99-102
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of edaravone postconditioning and remote ischemic postconditioning on myocardial ischemia/reperfusion (I/R) injury in rats.Methods Forty male Sprague-Dawley rats,aged 8 weeks,weighing 250-300 g,were randomly divided into 5 groups (n =8 each):sham operation group (group S); group I/R; edaravone postconditioning group (group E); remote ischemic postconditioning group (group P); edaravone postconditioning and remote ischemic postconditioning group (group EP).Myocardial I/R was induced by occlusion of anterior desending branch of left coronary artery for 30 min followed by 180 min reperfusion.Edaravone 3 mg/kg was injected intravenously at 1 min before reperfusion in groups E and EP.The animals underwent 10 min ischemia of bilateral hind limbs starting from 20 min of myocardial ischemia in groups P and EP.Left ventricular systolic pressure (LVSP),left ventricular end-diastolic pressure (LVEDP) and ± dp/dtmax were measured and recorded during reperfusion.Results Compared with group S,LVSP and ± dp/dtmax were significantly decreased and LVEDP was increased in the other groups (P ＜ 0.05).LVSP and ± dp/dtmax were significantly higher and LVEDP was lower during reperfusion in groups E,P and EP than in group I/R,and in group EP than in groups E and P (P ＜ 0.05).Conclusion Edaravone postconditioning and remote ischemic postconditioning can alleviate myocardial I/R injury and offers better efficacy than either alone.
