Association between polymorphism of α-Synuclein gene and Parkinson's disease of Uygurs nationality in Xinjiang
10.3760/cma.j.issn.0254-9026.2013.03.013
- VernacularTitle:a-突触核蛋白基因多态性与新疆维吾尔族帕金森病相关性研究
- Author:
Qiuxia SONG
;
Xiaoying ZHANG
;
Yanyun LI
;
Yan LIU
- Publication Type:Journal Article
- Keywords:
Uygur ethnic;
Han ethnic;
Parkinson's disease;
α-Synuclein (SNCA) gene;
Polymorphism
- From:
Chinese Journal of Geriatrics
2013;(3):286-290
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between the single-nucleotide polymorphism (SNP) rs3822086 site of the α-Synuclein(SNCA)gene and Parkinson's disease (PD) of Uygurs versus Hans in Xinjiang,and to compare the distribution difference of this polymorphic site between the Uygurs and Hans.Methods The rs3822086 polymorphism was determined by polymerase chainreaction restriction fragment length polymorphism (PCR-RFLP) in 237 patients with idiopathic Parkinson's disease (IPD,including 92 Uygurs and 145 Hans) and 247 health controls (including 103 Uygurs and 144 Hans).Results In the group aged ≥60 years,the T/T,C/T genotypes and T allele frequency were higher in PD group (196 cases) than in control group (196 cases) (25.5％ vs.20.9％,52.0％ vs.44.4％ and 51.5％ vs.43.1％),for genotype:P=0.027,allele:P=0.018.Between the Uygur versus Han nationality population,the T/T,C/T genotype and T allele frequency in the Uygurs were lower than in the Hans (15.4％ vs.30.4 ％,45.6％ vs.50.5％ and 38.2％ vs.55.7％),for genotype:P =0.000,allele:P =0.000.Conclusions The SNP rs3822086 site of SNCA gene may be a potential susceptibility site of IPD patients over the age of 60 years in Xinjiang,and rs3822086C/T + T/T is susceptible genotypes and rs3822086T is susceptible alleles.The distribution of rs3822086 polymorphism of SNCA might have a significant difference between the Xinjiang Uygur and Han populations.
