Plasma brain natriuretic peptide levels in elderly male patients with type 2 diabetes and primary osteoporosis
10.3760/cma.j.issn.0254-9026.2013.03.007
- VernacularTitle:老年男性2型糖尿病并存骨质疏松症患者血浆脑钠肽的变化
- Author:
Hexin ZHENG
;
Ying JIANG
;
Hong HUANG
;
Fang YUAN
;
Tianfeng WU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Osteoporosis;
Natriuretic peptide,brain
- From:
Chinese Journal of Geriatrics
2013;(3):263-266
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate plasma natriuretic peptide brain (BNP) levels in elderly male patients with type 2 diabetes and primary osteoporosis.Methods A total of 122 elderly male patients with type 2 diabetes were divided into 3 groups according to bone mineral density(BMD):normal group (41 cases),osteopenia group (40 cases) and osteoporosis group (41 cases),and another 33 age matched healthy subjects as control group.Plasma BNP levels were determined by ELISA.Results Plasma BNP levels in osteoporosis group [(1.95 ± 0.49) pmol/L] and osteopenia group [(1.64±0.48) pmol/L] were significantly elevated compared with that in normal group [(1.32±0.38) pmol/L] and control group [(1.26±0.39) pmol/L] (all P＜0.01).There was a statistical difference between osteoporosis group and osteopenia group (t=3.539,P＜0.05),and also between normal group and control group (t=2.726,P＜0.05).Plasma BNP levels had negative correlation with BMD of 2na-4th lumbar vertebra (r=-0.366) and femoral neck (r=-0.375),body mass index (r=-0.288) and estrodiol (E2) (r=-0.352) (all P＜0.05); while had a positive correlation with parathyroid hormone (PTH) (r=0.353,P＜0.05).Conclusions With BMD declining,plasma BNP levels are elevated in elderly male type 2 diabetes,which may be related to the compensatory increase in PTH and the decrease in estradiol.
