Role of IL-10 gene polymorphisms in promotor region in HLA matched sibling donor allogeneic hematopoietic stem cell transplantation
10.3760/cma.j.issn.0254-1785.2012.12.009
- VernacularTitle:供、受者IL-10基因多态性对异基因造血干细胞移植疗效的影响
- Author:
Xiaojin CAI
;
Axia SONG
;
Hua WANG
;
Ping ZHANG
;
Guixin ZHANG
;
Fan YANG
;
Jialin WEI
;
Qiaoling MA
;
Zhangsong YAN
;
Erlie JIANG
;
Yong HUANG
;
Dongling YANG
;
Mei WANG
;
Yi HE
;
Sizhou FENG
;
Mingzhe HAN
- Publication Type:Journal Article
- Keywords:
Interleukin-10;
Polymorphism,single nucleotide;
Hematopoietic stem cell transplantation;
Graft versus host disease;
Prognosis
- From:
Chinese Journal of Organ Transplantation
2012;(12):732-736
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the impact of IL-10 gene polymorphisms on the outcome in HLA matched sibling hematopoietic stem cell transplantation (HSCT).Methods PCR-sequencespecific primer (PCR-SSP) assay was used to analyze the SNP of IL-10 in 77 recipient and donor pairs:-1082 A/G,-819 T/C,-592 C/A.Results IL-10 ATA/ATA (1082,-819,-592) genotype in recipients significantly decreased the incidence of grade Ⅱ-Ⅳ acute graft vursus-host disease (aGVHD) (6.1％ vs.25.0 ％,P＜0.05),reduced 5-year transplant-related mortality (TRM) (10.7 ％± 5.9％ vs.29.7％ ± 5.2％,P＜0.05) and increased disease free survival (DFS) (81.8％ ± 6.7％ vs.56.8％ ± 7.5％,P＜0.05).With regard to the donor genotype,the incidence of grade Ⅱ-Ⅳ aGVHD,extensive chronic GVHD,5-year TRM and DFS had no signicant difference between IL-10 ATA/ATA and non ATA/ATA subgroup.Multivariable analysis also revealed that IL-10 non-ATA/ATA genotype in recipients and high-risk status of disease were two independent risk factors for DFS (HR =2.911,P =0.029; HR =2.686,P =0.027).Conclusion In HLA-matched sibling HSCT,the presence of recipient IL-10 ATA/ATA significantly decreased the incidence of grade Ⅱ-Ⅳ aGVHD and TRM,and increased DFS.
