Clinical outcomes in renal allograft recipients switched to long-term immunosuppressive therapy with mycophenolate mofetil after renal transplantation
10.3760/cma.j.issn.0254-1785.2012.12.005
- VernacularTitle:肾移植后不同时期转换为吗替麦考酚酯长期治疗的疗效观察
- Author:
Lizhong CHEN
;
Zhihong LIU
;
Bingyi SHI
;
Jianghua CHEN
;
Jianyu LING
;
Wei ZHANG
;
Genfu ZHANG
;
Jianhua AO
;
Yiping LU
;
Xiaodong ZHANG
;
Yu FAN
;
Ye TIAN
;
Lulin MA
;
Liming WANG
;
Shunliang YANG
;
Wujun XUE
;
Changsheng MING
;
Tongyu ZHU
;
Da XU
;
Xiangtie LI
- Publication Type:Journal Article
- Keywords:
Mycophenolate mofetil;
Kidney transplantation;
Calcineurin;
Glomerular Filtration Rate
- From:
Chinese Journal of Organ Transplantation
2012;(12):716-720
- CountryChina
- Language:Chinese
-
Abstract:
Objective To document the impact of conversion to mycophenolate mofetil (MMF)at different time points after transplantation on the renal function of renal function.Methods A longterm,multicenter,non-interventional and observational study was done.Two cohorts were included:One was Switch cohort (340 cases) including renal allograft recipients who switched to MMF at least 6 months after renal transplantation and followed up for 4 years after switch; The other was Stay cohort (123 cases),including renal allograft recipients who received MMF treatment after transplantation and followed up for 4 years after enrollment.Results GFR values of patients in Switch cohort was significantly increased after switch,and the change in GFR slope was 3.1 mL· min-1 · year-1 (P＜0.01).GFR values of patients in Stay cohort kept steady before and after enrollment,and the change in GFR slope was 0.44 mL·min-1 ·year-1 (P＞0.05).Statistically significant difference in the onset time of GFR decline (defined as 20％ decline from the baseline) was observed among subgroups within Switch cohort (P＜0.01),but there was no significant difference among subgroups within Stay cohort (P＞0.05).Stay cohort was 12％ higher than in Switch cohort every year.Conclusion Conversion to MMF ＞6 months or even many years after transplantation can obviously improve the renal function of recipients.The earlier conversion can benefit improvement of the renal function.
