Change of hepcidin expression in patients with hyperlipemia after allograft renal transplantation
10.3760/cma.j.issn.0254-1785.2012.10.007
- VernacularTitle:肾移植后伴发高脂血症受者血清hepcidin表达的变化
- Author:
Dong XUE
;
Xiaozhou HE
;
Xianlin XU
;
Ning XU
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Hyperlipidemias;
Interleukin-6;
Ferritins
- From:
Chinese Journal of Organ Transplantation
2012;(10):598-601
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the change and significance of hepcidin expression in patients with hyperlipemia after allograft renal transplantation.Methods Allograft renal transplantation recipients were divided into hyperlipemia group (n =35),and non-hyperlipemia group (n =25).Normal control group was divided into non-hyperlipemia subgroup (n =30),and hyperlipemia group (n =25).ELISA was used to detect serum hepcidin and IL6.Relevant indexes of hematology,biochemistry,and iron metabolism were examined.Results As compared with other three groups,hyperlipemia group after allogenic kidney transplantation had increased serum hepcidin,IL-6,and serum ferritin expression (P＜0.05).Single factor analysis of each group revealed that serum hepcidin expression was correlated with serum ferritin and IL-6 (P ＜ 0.05).Correlation analysis on all specimens demonstrated that serum hepcidin was correlated with glomerular filtration rate,total cholesterol,triglycerides,serum ferritin and IL6 expression (P＜0.05).Conclusion Renal allograft transplantion recipients with hyperlipemia have higher serum hepcidin expression; There exists correlation between the expression of serum ferritin and expression of IL-6,which could reflect the hyperlipemia-induced atherosclerosis and its progress.
