The effect of sarpogrelate on in-stent restenosis after percutaneous transluminal angioplasty in peripheral arterial disease

VernacularTitle:药物治疗对外周动脉硬化闭塞症支架术后再狭窄的影响
Author: Dan LIU ; Zhong CHEN ; Mengyao ZHAI ; Nan HE ; Xiaobin TANG ; Xuening ZHANG ; Qinghua WU
Publication Type:Journal Article
Keywords: Arterial occlusive diseases; Stents; In-stent restenosis; Sarpogrelate hydrochloride
From: Chinese Journal of General Surgery 2012;(11):896-899
CountryChina
Language:Chinese
Abstract: Objective To evaluate the impact of sarpogrelate on the in-stent restenosis (ISR) after percutaneous transluminal angioplasty (PTA) in peripheral arterial diseases (PAD).Methods PAD patients who had PTA for the first time were divided into two groups receiving respectively clopidogrel and aspirin (clopidogrel group) or sarpogrelate and aspirin (sarpogrelate group).Vascular ultrasonography was performed at 6 months after PTA in all patients to evaluate the degree of ISR.Results 62 patients finished the follow-up visits as required.The in-stent restenosis in the sarpogrelate group and clopidogrel group was 7.0％ vs.18.1％ (P =0.036),the peak systolic velocity ratio was 1.34 vs.2.08 (P =0.010) and the cases of ISR was 1 vs.10 (P =0.005) respectively.No patients reported serious adverse events.Conclusions Sarpogrelate combined with aspirin is safe and effective.Compare with clopidogrel and aspirin,sarpogrelate and aspirin can significantly reduce the rate of ISR after PTA and the intimal proliferation in the stent.