Establishment of animal model of intestinal motility disorders after severe craniocerebral trauma

VernacularTitle:重型颅脑损伤后肠动力障碍动物模型的建立
Author: Huan FANG ; Limei ZHANG ; Suofei ZHANG ; Jingci ZHU
Publication Type:Journal Article
Keywords: Craniocerebral trauma; Intestines; Kinetics; Models,animal
From: Chinese Journal of Trauma 2013;(2):165-169
CountryChina
Language:Chinese
Abstract: Objective To build model of intestinal motility disorders (IMD) in mice after severe craniocerebral trauma by using modified free fall impact method so as to lay the foundation for further study on development mechanism of postinjury IMD.Methods Severe craniocerebral trauma in mice was induced by a cylindrical sleeve rod impactor.Pathological changes of cerebral and intestinal tissue in mice were observed at 1,6 hours and 1,3,7 days after severe craniocerebral trauma.Brain water content and intestinal propulsion percentage were detected in each time point as well.Results Acute inflammation and congestion of the intestine were observed in phase of cerebral hemorrhage and edema after severe craniocerebral trauma in mice.Brain water content was increased at 6 hours and reached the peak at 24 hours.Intestine propulsion percentage showed a fall at one hour and dropped to the lowest level at 6 hours.Conclusions IMD exists in mice with severe craniocerebral trauma.The device involving modified Feeney free fall impact method can successfully establish animal model of IMD in mice with severe craniocerebral trauma.