Changes of platelet microparticles and its clinical significance in severely burned patients

VernacularTitle:烧伤患者血小板微粒的变化及临床意义
Author: Jiajun TANG ; Jingning HUAN
Publication Type:Journal Article
Keywords: Burns; Infection; Blood platelets
From: Chinese Journal of Trauma 2012;(10):881-884
CountryChina
Language:Chinese
Abstract: ObjectiveTo investigate the clinical significance of changes of platelet microparticles (PMPs) in burn and burn infection patients.MethodsThe patients were divided into burn shock group (n =44),burn infection group (n =33) and control group (n =11 ).Plasma PMPs were determined by flow cytometry and were recorded in absolute value and in particle proportion.Also,the frequently used biochemical indicators were detected and analyzed for their relationship with PMPs.ResultsCD41 + PMPs levels in the burn shock and burn infection groups were higher than those in the control group (P ＜ 0.01 ) and they showed positive relation with extent of burn ( r =0.258,P ＜ 0.05 ).Stepwise regression analysis indicated that r-glutamyltranspeptidase (r-GT),extent of burn and alanine aminotransferase (ALT) entered CD41 + PMPs level regression equation.ConclusionThe increase of PMPs levels may be closely correlated with the pathological coagulation state in severe burn patients.