Effects of percutaneous coronary interventional procedures on plasma levels of high sensitive C-reactive protein and interlekin-6 in patients with coronary artery disease
10.3760/cma.j.issn.1008-6315.2013.03.014
- VernacularTitle:冠状动脉介入治疗对冠心病患者血浆超敏C反应蛋白和白细胞介素6水平的影响
- Author:
Lijun LIU
;
Yanxia MA
;
Huimin FENG
;
Lili SHAO
;
Limin PEI
;
Limin MENG
;
Shuxiang LI
- Publication Type:Journal Article
- Keywords:
Coronary artery disease;
C-reactive protein;
Interlekin-6
- From:
Clinical Medicine of China
2013;(3):275-277
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of percutaneous coronary interventional (PCI) on the inflammatory indices and postoperative vascular restenosis.Methods This study involved 90 patients undergoing PCI procedures for Coronary artery disease (CAD) compromising a single coronary artery.Fourty healthy individuals with normal findings by coronary angiography were selected as the control group.Before and after PCI or coronary angiography,plasma hs-CRP and IL-6 were measured in all the subjects by immunonephelometry and enzyme-linked immunosorbant assay (ELISA),respectively.Results (1) In the CAD patients,the plasma hs-CRP level was significantly elevated after PCI as compared with the preoperative level((18.69 ±5.14) mg/L vs (14.45 ± 4.32) mg/L,t =1.42,P ＜ 0.01),whereas in the control group,the hs-CRP level underwent no significant changes after coronary angiography((13.59 ±5.99) mg/L vs(12.46 ±5.35) mg/L,t =1.25,P ＞ 0.05).(2) PCI procedures also resulted in significant elevation of plasma IL-6 level in the CAD patients((1.87±0.45) pg/L vs (1.35 ±0.39) pg/L,t =1.33,P＜0.01),but in the control group,IL-6 showed no significant variation after coronary angiography ((1.32 ± 0.41) pg/L vs (1.21 ± 0.38)pg/L,t =1.16,P ＞ 0.05).We observed significant difference of hs-CRP and IL-6 levels between the CAD patient group and the control group (t =4.96,6.61 respectively,P ＜ 0.01).Conclusion Plasma hs-CRP and IL-6 are elevated in CAD patients following PCI procedures.But the roles of elevated hs-CRP and IL-6 in the vascular restenosis following the procedures need further investigation.
