Correlation of myeloperoxidase and carotid atherosclerosis in diabetic patients on maintenance hemodialysis
10.3760/cma.j.issn.1008-6315.2013.03.012
- VernacularTitle:维持性血液透析的糖尿病患者血浆髓过氧化物酶与颈动脉硬化关系的研究
- Author:
Zhanyun ZHAO
;
Bingli YAN
;
Chunguang WANG
;
Song LI
;
Lihai HAO
;
Lili YIN
- Publication Type:Journal Article
- Keywords:
Hemodialysis;
Myeloperoxidase;
Diabetic;
Carotid atherosclerosis disease
- From:
Clinical Medicine of China
2013;(3):267-270
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study possible clinical relationships of myeloperoxidase (MPO) and carotid atherosclerosis in diabetic patients on maintenance hemodialysis(MHD).Methods Levels of plasma MPO and serum elastase (ELT) of diabetic patients on MHD were determined by enzyme-linked immunosorbent assay.Carotid intima media thickness(CIMT),quantity and area of carotid plaque were measured by B-mode ultrasonography.Results Plasma MPO was significantly higher after hemodialysis(HD) than before HD(414.6 (198.9,671.5) μg/L vs 176.4 (69.9,243.3) μg/L,Z =-4.51,P < 0.01).There was no significant difference of serum ELT before and after HD(198.0(146.9,270.5) μg/L vs 230.9(40.2,308.0) μg/L,Z =-1.87,P > 0.05).There was positive correlation between the age and CIMT,quantity or area of carotid plaqueor(correlation coefficient:0.764,0.416 and 0.446 respectively,P < 0.01 or P < 0.05),There was positive correlation between MPO level before HD and age,Levels of serum ELT before HD,or CIMT(correlation coefficient:0.592,0.476 and 0.810 respectively,P < 0.01).There was positive correlation between MPO level after HD and levels of serum ELT after HD (correlation coefficient:0.364,P < 0.05).There was no correlation between the levels of plasma MPO after HD and CIMT,quantity or area of carotid plaqueor (P > 0.05).Conclusion (1) Age and MPO level before HD contribute to carotid atherosclerosis in patients on MHD.(2)There was no relation between higher MPO level after HD and carotid atherosclerosis.