Clinical observation on the serum levels of heat shock protein 70 in uremic patients with different dialysis ages
10.3760/cma.j.issn.1008-6315.2013.02.002
- VernacularTitle:不同透析龄尿毒症患者热休克蛋白70表达的临床观察
- Author:
Kun LIU
;
Xinzhi ZHANG
;
Xiuli FEI
;
Congchong ZHANG
;
Bing SHEN
- Publication Type:Journal Article
- Keywords:
Dialysis ages;
Uraemia;
Haemodialysis;
Heat shock protein 70
- From:Clinical Medicine of China
2013;(2):117-120
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum levels of heat shock protein 70 (HSP70) in uremic patients with different dialysis ages.Methods Ninety-two maintenance haemodialysis patients were divided into short-term group(from three months to 2 years,n =32),median-term group(from 2 to 5 years,n =37) and longterm group(more than 5 years,n =23) according to different dialysis ages.Enzyme-linked immunosorbent assay (ELISA) was used to measure the serum levels of HSP70 before and after haemodialysis in each group.Results The semm levels of HSP70 had significant difference both in median-term group and long-term group before and after haemodialysis(median-term group:(54.94 + 39.21) μg/L vs (69.72 + 39.90) μg/L,t =-2.068,P =0.047 ;long-term group:(46.17 +34.63) μg/L vs (74.07 ±41.11) μg/L,t =-2.814,P =0.010).But there was no statistics difference on the serum levels of HSP70 before and after haemodialysis in the short-term group((70.42 ±38.30) μg/L vs (62.89 ±43.01) μg/L,t =0.870,P =0.390).Conclnsion Haemodialysis patients with more stress protection ability are likely to obtain long term survival.
