The change of PAI-1 and TNF-α in old patients with metabolic syndrome and the effect of metformin
10.3760/cma.j.issn.1008-1372.2012.12.008
- VernacularTitle:PAI-1和TNF-α在老年代谢综合征患者中的变化及二甲双胍对其影响
- Author:
Manxiang DENG
;
Huixia LIU
;
Ji ZHANG
;
Youbo YANG
- Publication Type:Journal Article
- Keywords:
Plasminogen activator inhibitor 1/blood;
Tumor necrosis factor-alpha/blood;
Metabolic syndrome X/blood;
Metformin/therapeutic use
- From:
Journal of Chinese Physician
2012;(12):1606-1608
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation of PAI-1 and TNF-α and the pathophysiology of the metabolic syndrome (MS) and coronary heart disease,and explore the role of metformin in the MS.Methods Sixty cases of old patients with the MS were chosen.These patients were divided into two groups at random.One group interfered with living style and metformin,the other group only interfered with living style.The activity of PAI-1 was detected by chromogenic substrate method,and the level of TNF-α was detected by ELISA assay.Results (1) The levels of PAI-1 and TNF-α in the MS patients [(0.95 ± 0.05) AU/ml,(24.81 ± 3.87)ng/ml] were significantly higher than in normal old people[(0.66 ± 0.10)AU/ml,(10.76 ±2.00) ng/ml] (P ＜0.001) ;(2)The levels of PAI-1 and TNF-α in the MS patients with CHD [(0.96 ± 0.05) AU/ml,(26.12 ± 2.83) ng/ml] were significantly higher than those in the patients without CHD [(0.94 ± 0.03) AU/ml,(23.71 ± 4.27) ng/ml] (P ＜ 0.05) ;(3)The activity of PAI-1 and the level of TNF-α in the metformin group was decreased significantly [△ was (0.20 ± 0.17)AU/ml,(4.42 ± 0.85ng/ml),P ＜0.01],and metformin can improve the components of the MS.Conclusions The old patients with MS is prone to develop cardiac vascular disease.PAI-1 and TNF-α participate in pathophysiology of the MS and its complication.Metformin can inhibit the expression of PAI-1 and TNF-α to suppress the components of the MS,and block the complication of the MS.
