Clinical Efficacy of Shenlingbaizhu Decoction on Immune Status in Patients with Ulcerative Colitis
10.3760/cma.j.issn.1008-6706.2012.22.015
- VernacularTitle:参苓白术散治疗溃疡性结肠炎的疗效及对患者免疫状态的影响
- Author:
Ruisheng ZHONG
;
Guihong CHEN
- Publication Type:Journal Article
- Keywords:
Ulcerative Colitis;
Shenlingbaizhu Decoction;
Immunity
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;(22):3391-3393
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore clinical efficacy of Shenlingbaizhu decoction on immune status in patients with ulcerative colitis(UC).Methods 60 patients with UC were selected and divided into control group and experiment group evenly and randomly.Control group received treatment of salazosulfapyridine,while experiment group received treatment of Shenlingbaizhu decoction based on treatments of control group.Clinical efficacy,serum levels of IL-6 and IL-8,percentage of Treg cells in peripheral blood were observed and compared between two groups before and after treatments.Results Total clinical efficacy of experiment group was significantly higher than that of control group(P＜0.05)(90.00％ vs 76.67％);Serum level of IL-6 was decreased significantly in all patients(P＜0.05),more significantly in experiment group(P＜0.05)after treatment;Serum level of IL-10 increased significantly in experiment group after treatment(P＜0.05);Percentage of Treg cells increased significantly in experiment group after treatment(P＜0.05).Conclusion Combination therapy of salazosulfapyridine and Shenlingbaizhu decoction shows significantly better clinical effects than salazosulfapyridine alone,probably via regulating immune status.
