Hypothesis and development of tumor pre-metastatic nich
10.3760/cma.j.issn.1673-4203.2012.12.014
- VernacularTitle:肿瘤转移前微环境假说及其研究进展
- Author:
Chao LI
;
Daren LIU
;
Xiaowen LI
;
Lingna HUANG
;
Guogang LI
;
Longyun YE
;
Yixiong ZHENG
;
Li CHEN
- Publication Type:Journal Article
- Keywords:
Tumor microenvironment;
Myeloid progenitor cells;
Microvesicles;
Neoplasm metastasis
- From:
International Journal of Surgery
2012;(12):836-839
- CountryChina
- Language:Chinese
-
Abstract:
Tumor invasion and metastasis are regarded as main reasons for the failure of therpy and the reason of patients death.The mechnism of tumor metastasis is still uncertain.The pre-metastatic niche hypothesis provides us with new ideas to discover the mechnism.Numerous materials are involved in the formation of the pre-metastatic niche according to this hypothesis,including bone marrow-derived cells,microvesicles,exosomes,CD44,and so on.A further research on this hypothesis helps to deeply understand the nature of metastasis and leads clinical doctors to explore novel targets for clinical diagnoses and therapies.
