Should all patients with ischemic stroke use high-dose statins?
10.3760/cma.j.issn.1673-4165.2012.11.012
- VernacularTitle:所有缺血性卒中患者都应该使用大剂量他汀类药物吗?
- Author:
Kejiang SU
- Publication Type:Journal Article
- Keywords:
Stroke;
Brain Ischemia;
Hydroxymethy lglutaryl-CoA Reductase Inhibitors
- From:
International Journal of Cerebrovascular Diseases
2012;(11):875-880
- CountryChina
- Language:Chinese
-
Abstract:
Statin therapy has become a standard method for the prevention of ischemic stroke,and is becoming a treatment option for acute ischemic stroke.The pleiotropic effects of statins which are independent of cholesterol are the main basis of using them in the treatment of ischemic stroke.It is regarded that these pleiotropic effects may have neuroprotective effects,thus improving the neurological functional outcome of patients.At the same time,studies have shown that the therapeutic effect of statins has dose-dependent manner; therefore,we advocate using high-dose statin therapy.However,about whether high-dose statins should be used in patients with ischemic stroke of the different mechanisms remain controversial.
