Src kinases and cerebrovascular diseases
10.3760/cma.j.issn.1673-4165.2012.10.015
- VernacularTitle:Src激酶与脑血管病
- Author:
Xianhua ZHANG
;
Meihua LI
- Publication Type:Journal Article
- Keywords:
src-Family Kinases;
Brain Ischemia;
Cerebral Hemorrhage;
Intracranial Aneurysm
- From:
International Journal of Cerebrovascular Diseases
2012;(10):796-800
- CountryChina
- Language:Chinese
-
Abstract:
Src family kinases (SFKs) are the largest non-receptor tyrosine kinase family and play key roles in the regulation of cell morphology,proliferation,growth,adhesion,and motility.The activation of src kinases couples with many signals input on cell surface,including growth factor,cytokine,immune cell receptor,G protein-coupled receptor,integrin,and other cell adhesion molecules.In addition,as an important molecular switch connecting many extracellular and intracellular important signaling pathways,src kinases also play an important role in the occurrence of cerebrovascular diseases.
