Advances in genomics for ischaemic stroke
10.3760/cma.j.issn.1673-4165.2012.10.006
- VernacularTitle:缺血性卒中的基因组学研究进展
- Author:
Pan PAN
;
Manshu SONG
- Publication Type:Journal Article
- Keywords:
Stroke;
Brain Ischemia;
Genomics;
Genetic Association Studies;
Genome-Wide Association Study;
Polymorphism,Single Nucleotide;
Risk Factors
- From:
International Journal of Cerebrovascular Diseases
2012;(10):751-756
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke is one of the major diseases of causing adult disability and death.Age,sex,smoking,hypertension,and diabetes,etc.are the risk factors for ischemic stroke,but they can only partially explain the reasons of stroke onset.Twins,families,and single-gene genetic stroke studies have shown that ischemic stroke has obvious genetic predisposition.In recent years,genomics has made remarkable progress in ischemic stroke study and has shown that many new single nucleotide polymorphisms or genes are associated with ischemic stroke and its risk factors.However,the contribution of these genetic genes for ischemic stroke is still too small and the repetitive studies are needed for further confirmation.
