Statins may promote stroke-associated pneumonia recovery and not affect stroke outcome: a retrospective case series study
10.3760/cma.j.issn.1673-4165.2012.10.002
- VernacularTitle:他汀类药物可促进卒中后肺炎恢复但不影响卒中转归:回顾性病例系列研究
- Author:
Ting WU
;
Qin WANG
;
Yan CHEN
;
Min LI
;
Zhiqing LIU
;
Jianguo SUN
- Publication Type:Journal Article
- Keywords:
Stroke;
Brain Ischemia;
Pneumonia;
Hydroxymethylglutaryl-CoA Reductase Inhibitors;
Prognosis
- From:
International Journal of Cerebrovascular Diseases
2012;(10):727-731
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of statin therapy on pneumonia and stroke outcome after acute ischemic stroke.Methods The patients with pneumonia after acute ischemic stroke were enrolled retrospectively.The demographic and clinical data of the patients were collected,including whether using statins,the clinical features of pneumonia,the days of using antibiotics,and neutrophil count.They were divided into either a statin group or a control group according to whether they used statins or not.Stroke outcome was evaluated with the modified Rankin scale.Results A total of 53 patients with pneumonia after acute ischemic stroke were enrolled in the study,20 of them were in the statin group and 33 were in the control group.There were no significant differences in age and the proportions of male and complicated with hypertension,diabetes and coronary heart disease between the statin group and the control group (all P ＞ 0.05).The cure rate,improvement rate,invalid rate and mortality in the statin group were 50.00％,35.00％,15.00％ and 0.00％,respectively; and in the control group were 15.15％,39.40％,33.30％ and 15.15％,respectively.There were significant differences (P =0.003).The days of temperature returning to normal (2.10 ± 3.29 d vs.4.61 ±3.54 d; P =0.002),pulmonary rales disappearing (3.60 ±2.46 d vs.7.67 ±4.09 d; t =-4.019,P =0.000)and using antibiotics (7.05 ± 3.13 d vs.9.73 ± 4.00 d; t =-2.562,P =0.013) in the statin group were significantly shorter than those in the control group,while there were no significant differences in the days of cough and sputum production retuming to normal between the 2 groups.The proportions of diabetes (20.83％ vs.55.17％ ;x2 =6.473,P =0.011),posterior circulation stroke (4.7％ vs.27.59％ ; P =0.031)and bilateral lung shadows (29.17％ vs.55.17％ ;x2 =5.705,P=0.017),as well as baseline National Stroke Association NIH Stroke Scale (NIHSS) score (4.00 ± 4.54 vs.10.66 ± 6.33; t =1.898,P =0.001) in a good outcome group were significantly lower than those in a poor outcome group.But there was no significant difference in the proportion of the patients treated with statins between the good outcome group and the poor outcome group (41.67％ vs.34.48％ ;x2 =0.288,P =0.591).Multivariate logistic regression analysis showed that diabetes (odds ratio [OR] 5.146,95％ confidence interval [CI] 1.166-22.709; P =0.031) and baseline NIHSS score (OR 1.251,95％ CI 1.080-1.449; P =0.003) were the independent risk factor for patient with poor outcomes.Conclusions Statins may promote the pneumonia recovery in patients with acute ischemic stroke; however,it has no effect on stroke outcome.
