Efficacy of midazolam combined with remifentanil for lower eyelid blephamoplasty
10.3760/cma.j.issn.1671-0290.2012.06.012
- VernacularTitle:咪达唑仑联合瑞芬太尼在睑袋成形术麻醉中的应用
- Author:
Xiang LI
;
Junjie ZHU
;
Huiyu CHEN
- Publication Type:Journal Article
- Keywords:
Midazolam;
Remifentanil;
Lower eyelid blephamoplasty
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2012;(6):437-439
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of midazolam combined with remifentanil for lower eyelid blephamoplasty.Methods In a double-blind study,200 patients undergoing lower eyelid blephamoplasty were randomly and equally divided into 2 groups (100 cases each):test group (midazolam 0.05 mg/kg and remifentanil 0.5 μg/kg followed by remifentanil 0.05 μg/(kg·min) and control group (midazolam 0.05 mg/kg).Heart rate (HR),mean arterial pressure (MAP),and pulse oxygen saturation (SpO2),respiratory rate (RR),SpO2 change,operation time,recovery time,the incidence of adverse reactions and the satisfactory rate of both patients and surgeons were monitored and recorded before the medication,3 min after the medication,at beginning of the surgery,during and immediately after the surgery,and 30 min after surgery.Results Two groups of patients had no obvious difference in intraoperative MAP,HR,RR,SpO2 and postoperative recovery time (P＞0.05);the incidence of postoperative nausea and vomiting in the test group was significantly higher than that in control group (P＜0.05); Patients and surgeons satisfaction in the test group was higher than that in control group (91.3±11.6)vs (52.7±10.4) (P＜0.05).Conclusions Midazolam combined with remifentanil for lower eyelid blephamoplasty has less inhibitory effect on circulatory and respiratory functions and the patients come round fast after surgery.But there are risks of respiratory inhibition in the induce phase and nausea and vomiting in the recovery stage.
