Efficacy of triple therapy and sequential therapy in the eradication of Helicobacter pylori in patients receiving long-term non-steroidal anti-inflammatory drugs treatment
10.3760/cma.j.issn.0254-1432.2012.12.003
- VernacularTitle:三联疗法与序贯疗法在长期服用非甾体类抗炎药人群中根除幽门螺杆菌的疗效观察
- Author:
Xinxin HUANG
;
Lishou XIONG
;
Shiyang MA
;
Peng BAI
;
Yugang DONG
;
Xiuyan YANG
;
Xiuren GAO
;
Liuqin LIANG
;
Liya ZHOU
;
Minhu CHEN
- Publication Type:Journal Article
- Keywords:
Anti-inflammatory agents,non-steroidal;
Helicobacter pylori;
Drug therapy,combination
- From:
Chinese Journal of Digestion
2012;(12):814-817
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy of triple therapy and sequential therapy in the eradication of Helicobacter pylori (Hp) in patients receiving long-term non-steroidal antiinflammatory drugs (NSAID) treatment.Methods Patients receiving long-term NSAID treatment were enrolled in this study.Patients diagnosed as Hp infection were divided into triple therapy and sequential therapy groups.The patients in triple therapy group received omeprazole,clarithromycin and amoxicillin theray for 10 days.The patients in sequential group received esomeprazole with amoxicillin for five days,and then esomeprazole with clarithromycin and metronidazole for another five days.All patients were given mucosal protective therapy as maintenance treatment after eradication therapy and followed up for 12 weeks.Patients underwent endoscopy examination and Hp testing before and after follow-up.Hp eradication rates were compared with the intention-to-treat (ITT) and per protocol (PP) analysis.Results According to ITT analysis,the eradication rates of Hp in triple therapy group and sequential therapy group were 78.4 ％ (40/51) and 80.0 ％ (40/50) respectively,there was no significant difference between these two groups (x2 =0.038,P=0.846).According to PP analysis,the eradication rates of Hp in triple therapy group and sequential therapy group were 84.4％ (38/45) and 87.0％ (40/46) respectively,there was no significant difference between these two groups either (x2=0.117,P=0.732).Conclusion There was no significant difference in Hp eradication between triple therapy and sequential therapy in patients receiving long-term NSAID treatment.
