How massage inhibits scar tissue formation in skeletal muscles after blunt injury
10.3760/cma.j.issn.0254-1424.2012.010.006
- VernacularTitle:按摩抑制兔钝挫伤骨骼肌瘢痕形成的机制研究
- Author:
Renjian LIU
;
Chenglin TANG
;
Min ZHOU
;
Jie GAO
;
Hui XIE
;
Xiaolin CHEN
- Publication Type:Journal Article
- Keywords:
Massage;
Skeletal muscle;
TGF-β1;
COL-Ⅰ
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2012;(10):742-746
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of massage on quadriceps femoris repair after injury by external force and the expression of transforming growth factor β1 (TGF-β1) and collagen-Ⅰ (COL-Ⅰ) mRNA.To explore the molecular mechanisms inhibiting scar tissue formation and promoting muscle repair.Methods Forty New Zealand white rabbits weighing (2.0 ±0.5) kg were randomly divided into a normal control group (A) (n =4),a selfrepair group (B) (n =20,further divided into the 3rd,7th,11th,15th and 19th day time points),and a massage group (C) (n =16,further divided as in group B).In group A the rabbits were not treated,as normal controls.In groups B and C rabbit models of quadriceps femoris injury were prepared using a self-made beater.In group B no massage therapy was given as a natural recovery control; in group C,massage therapy was given after 5 days.Realtime quantitative PCRs were used to detect TGF-β1 and COL-Ⅰ mRNA expression.Resnlts There was no significant difference between groups B and C in the expression of TGF-β1 or COL-Ⅰ mRNA on day 7.At the later time points,expression of both mRNAs in group C was significantly less than in group B.Conclusion Massage can effectively reduce the expression of TGF-β1 and COL-Ⅰ mRNA,inhibit excessive scar formation and promote repair of injured tissue.
