The effects of rehabilitation training on amyloid-beta peptide and insulin-degrading enzyme levels in the hippocampus of rats with vascular dementia
10.3760/cma.j.issn.0254-1424.2012.010.001
- VernacularTitle:康复训练对血管性痴呆大鼠海马β淀粉样多肽及胰岛素降解酶的影响
- Author:
Qing YE
;
Hongwei WANG
;
Yong YOU
;
Haifen HUANG
;
Huiying LIAO
;
Si PAN
;
Yan HUANG
- Publication Type:Journal Article
- Keywords:
Vascular dementia;
Rehabilitation;
Amyloid-beta peptide;
Insulin-degrading enzyme
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2012;(10):721-724
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of rehabilitation training on hippocampal amyloid-beta peptide (Aβ) and insulin-degrading enzyme (IDE) levels in vascular dementia (VD).Methods Thirty female Sprague-Dawley rats were randomly assigned to a rehabilitation group (n =10),a model group (n =10) or a sham-operation group (n =10).An experimental VD model was established in the rats of the first 2 groups by bilateral common carotid artery permanent ligation.The rats in the rehabilitation group then received 1 h of rehabilitation training daily.Learning and memory were assessed at 4 weeks aftet the operation.Immunohistochemical staining was used to detect Aβ and IDE expression in the hippocampus dentate gyrus (DG) area.Results The rats in the rehabilitation group showed significantly better learning ability compared with the model group.The expression of Aβ in the rehabilitation group was significantly less than in the model group.The expression of IDE in the rehabilitation group was significantly greater Conclusion Rehabilitation can accelerate the recovery of learning and memory in VD,at least in rats The mechanism is possibly related to decreased accumulation of Aβ in the hippocampus due to up-regulation of the expression of IDE.
