Lateralizing language area and assessing hemispheric memory function by intracarotid injecting propofol
10.3760/cma.j.issn.1006-7876.2012.11.005
- VernacularTitle:颈内动脉内注射丙泊酚定侧语言区和评价半球记忆功能
- Author:
Liankun REN
;
Zhaohui TIAN
;
Zhiyong ZHANG
;
Jia CHEN
;
Dongyan WU
;
Xiaoxuan LI
;
Weihe ZHANG
;
Pei RONG
;
Shuang XUE
;
Jinsong JIAO
- Publication Type:Journal Article
- Keywords:
Epilepsies,partial;
Language;
Memory;
Propofol;
Injections,intra-arterial;
Carotid artery,internal
- From:
Chinese Journal of Neurology
2012;(11):787-791
- CountryChina
- Language:Chinese
-
Abstract:
Objective In the context of worldwide shortage of amytal,explore the intracarotidpropofol test for lateralizing language area and assessing hemispheric memory function.Methods Fourteen patients with refractory partial epilepsy who were candidates for surgical intervention were included in the study.With guide under a digital subtraction angiography,propofol was injected in bilateral intracarotidsequentially.Muscle power deceasing to level 0 at the contralateral limb and eyes gazing to contralateral side were used as the mark of hemispheric anesthesia completely.The immediate language alterations were recorded.To evaluate the bilateral language and memory functions,the visual and auditory memory tasks were performed sequentially once patient could concentrate his attention ; and after limb muscle power recovering to normal level,patients were required to perform a free recall test.Any abnormal responses were recorded.Results Language dominant hemisphere was determined in 14 patients.Nine patients were confirmed as left language dominance,2 patients were right language dominance.The remained 3 patients were considered as bilateral language dominance.Meanwhile,the hemispheric memory function was able be evaluated in 13 patients.More than 67％ memory function was sustained in hemisphere contralateral to mesial temporal lesions.Transient responses including eye pain,facial muscle spasms,laughers and involuntary movements were observed.Conclusion Hemispheric language and memory functions can be assessed with direct intracarotidpropofol injection,and propofol could be an alternative drug to amobarbital used in the Wada test.
