Therapy monitoring of combined detection of ProGRP and neuron-specific enolase in small cell lung cancer patients

VernacularTitle:胃泌素前体释放肽片段和神经元特异性烯醇化酶联合监测小细胞肺癌患者的病情和疗效
Author: Xiaomin LI ; Yajuan WU ; Qi LI ; Wenhua CHENG ; Yaqiong REN
Publication Type:Journal Article
Keywords: Carcinoma,small cell; Treatment outcome
From: Chinese Journal of General Practitioners 2013;(3):207-209
CountryChina
Language:Chinese
Abstract: Before and after treatment as well as before metastasis,the combined detection of progastrin-releasing peptide (ProGRP) and neuron-specific enolase (NSE) was performed in 150 patients with small cell lung cancer.The follow-up period was 1 year.Enzyme-linked immunosorbent assay (ELISA) and electrochemiluminescence immunoassay were conducted.The result showed a negative correlation between the serum levels of ProGRP and NSE the curative effect.And a positive correlation existed between the serum levels of ProGRP and NSE and disease development.The difference had statistical significance (P ＜ 0.05).The levels of ProGRP and NSE may be used to indicate the disease development and evaluate the curative effect.