Relationship between pulmonary arterial hypertension and fibrinolysis in elder patients with chronic obstructive pulmonary disease
10.3760/cma.j.issn.1671-7368.2013.03.020
- VernacularTitle:老年慢性阻塞性肺疾病患者肺动脉高压与纤溶功能的关系
- Author:
Li HAN
;
Yihong DING
;
Linzhi XIAO
;
Ying ZHANG
;
Zhengyan CHEN
;
Qin LIU
;
Bin XU
;
Guochao SHI
- Publication Type:Journal Article
- Keywords:
Pulmonary disease,chronic obstructive;
Hypertension,pulmonary
- From:
Chinese Journal of General Practitioners
2013;(3):205-206
- CountryChina
- Language:Chinese
-
Abstract:
A total of 40 patients with COPD (excluding those with correlated/relevant diseases)were measured for inflammation parameters of erythrocyte sedimentation rate (ESR) and c-reactive protein (CRP) after hospital admission and some coagulation/fibrinolysis parameters including D-dimer,thrombinantithrombin (TAT),prothrombin fragment 1 + 2,(tissue plasminogen activator) tPA,plasminogen activator inhibitor 1 (PAI-1),von Willebrand factor (von WF),endothelin receptor A,thromboxane B2,P-selectin and pulmonary arterial pressure (PAP) by ultrasonic cardiography after the settling of the symptons of acute period.All patients were then divided into 2 groups according to PAP [＜ 40 mm Hg (1 mmHg=0.133 kPa) (n=24),＞40 mm Hg (n=16)].The values of CRP and ESRin the group with PAP ＞ 40 mm Hg were significantly higher than those in another group (P =0.044 and P =0.002respectively) while tPA was lower (P =0.04).A moderate positive correlation existed between tPA and TXB2 (r =0.547).Moreover,a highly positive correlation was found between TXB2 and PAl-1 (r =0.929).The results indicated that the COPD patients with pulmonary arterial hypertension (PAH) tend to have a higher level of inflammation,and their fibrinolysis becomes impaired leading to a prothrombotic state.
