Combination of kidney transplantation with hematopoietic stem cell infusion

VernacularTitle:造血干细胞输注在肾移植中的临床应用
Author: Yongchao GE ; Zhiyu WANG ; Xiaowu ZHAO ; Shuyi WU ; Li ZAHNG ; Jinshun FENG ; Kun DUAN ; Shilin CHEN ; Quanxi GUO ; Tao ZHENG ; Baodong CHANG ; Zhihao YUAN ; Fen QIN
Publication Type:Journal Article
Keywords: Kidney transplantation; Transplantation tolerance
From: Chinese Journal of General Practitioners 2012;(12):934-936
CountryChina
Language:Chinese
Abstract: Ninety six female patients with chronic renal failure were randomly allocated into combination group (n =48) and control group (n =48).In combination group patients received both kidney transplantation and hematopoietic stem cell infusion,in control group patients underwent kidney transplantation only.The results showed that chronic rejection in the combination group was lower than that in the control group [2％(1/48)vs.17％ (8/48),P＜0.05)].The 1-,3-,5-and 10 y-survival rates of kidney in the combination group were 98％ (47/48),94％ (45/48),83％ (34/41) and 9/17,respectively,those in control group were 98％ (47/48),90％ (43/48),76％ (31/41) and 7/17,respectively.Infusion of donor hematopoietic stem cells can augment chimerism in early postoperative period and significantly reduce the rate of graft rejection,which is beneficial for the quality of life of the recipients.