SNPs in the SCGB3A2 promoter are associated with susceptibility to Graves' disease
10.3760/cma.j.issn.1000-6699.2012.12.010
- VernacularTitle:SCGB3A2基因启动子区SNPs与Graves病相关性研究
- Author:
Jun LIANG
;
Yu WANG
;
Shuangxia ZHAO
;
Jingyi SHI
;
Yongde PENG
;
Guanqi GAO
;
Chunming PAN
;
Guoyue YUAN
;
Bing HAN
;
Qing SU
;
Ling GAO
;
Mingdao CHEN
;
Jiajun ZHAO
;
Huaidong SONG
- Publication Type:Journal Article
- Keywords:
Graves'disease;
SCGB3A2 gene;
Promoter;
Polymorphism,single nucleotide
- From:
Chinese Journal of Endocrinology and Metabolism
2012;(12):989-993
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of single nucleotide polymorphisms (SNPs) in the SCGB3A2(secretoglobin family 3A member 2) gene promoter with susceptibility of Graves' disease.Methods One-hundred and seventy-nine SNPs within a 3.0 Mb region surrounding marker D5s2090 were scanned in a case-control study.The size of the region(s) associated with GD was then narrowed.Results Total 179 SNPs within a 3.0 Mb region surrounding marker D5s2090 were analyzed.The most significant association signal was found at SNP rs1368408 (P =3.69 × 10-5).Subsequent association analysis was then performed and the results suggested that the SNP76 (P =4.11 × 10-8) and SNP75 (P =1.37 × 10-8) in the promoter of SCGB3A2 gene may be the causal variants of GD.Logistic regression analysis suggested these 2 SNPs in this region may contribute to GD susceptibility.Conclusion A significant association seems to exist between GD with the SCGB3A2 gene.